Effect of Industry 4.0 on Education Systems: An Outlook

Congreso Universitario de Innovación Educativa En las Enseñanzas Técnicas, CUIEET (26º. 2018. Gijón

MEGARA-GTC stellar spectral library – II. MEGASTAR first release

MEGARA is an optical integral field and multi-object fibre-based spectrograph for the 10.4 m Gran Telescopio CANARIAS that offers medium-to-high spectral resolutions (FWHM) of R ≃ 6000, 12 000, 20 000. Commissioned at the telescope in 2017, it started operation as a common-user instrument in 2018. We are creating an instrument-oriented empirical spectral library from MEGARA-GTC stars observations, MEGASTAR, crucial for the correct interpretation of MEGARA data. This piece of work describes the content of the first release of MEGASTAR, formed by the spectra of 414 stars observed with R ≃ 20 000 in the spectral intervals 6420–6790 Å and 8370–8885 Å, and obtained with a continuum average signal-to-noise ratio around 260. We describe the release sample, the observations, the data reduction procedure and the MEGASTAR data base. Additionally, we include in Appendix A an atlas with the complete set of 838 spectra of this first release of the MEGASTAR catalogue.This work has been supported by MINECO-FEDER grants AYA2016-75808-R, AYA2016-79724-C4-3-P, RTI2018-096188-BI00, AYA2017-90589-REDT and has been partially funded by FRACTAL, INAOE, and CIEMAT

MEGASTAR - III. Stellar parameters and data products for DR1 late-type stars

© The Authors 2023. This work is part of the grants I+D+i RTI2018-096188-B-I00 and PID2019-107408GB-C41, which have been funded by Ministerio de Ciencia e Innovación and Agencia Estatal de Investigación (MCIN/AEI/10.13039/501100011033). It has been also partially funded by FRACTAL, INAOE and CIEMAT. S.R.B. thanks the financial support by MCIN/AEI/10.13039/501100011033 (contract FJC 2020-045785-I) and NextGeneration EU/PRTR and MIU (UNI/551/2021) through a Margarita Salas grant. This work is based on observations made with the Gran Telescopio Canarias (GTC), installed in the Spanish Observatorio del Roque de los Muchachos, in the island of La Palma. This work is based on data obtained with MEGARA instrument, funded by European Regional Development Funds (ERDF), through Programa Operativo Canarias FEDER 2014-2020. The authors thank the support given by Dr. Antonio Cabrera and Dr. Daniel Reverte, GTC Operations Group staff, during the preparation and execution of the observations at the GTC. This research made use of Astropy (Astropy Collaboration et al. 2018), a community-developed core Python package for Astronomy. This research has made use of the SIMBAD database and the VizieR catalogue access tool, CDS, Strasbourg, France (DOI: 10.26093/cds/vizier). The original description of the VizieR service was published in A&AS 143, 23. This work has made use of data from the European Space Agency (ESA) mission Gaia (https: //www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos. esa.int/web/gaia/dpac/consortium). Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. We are very grateful to the reviewer whose comments and suggestions have helped to improve the manuscript.MEGARA is the optical integral field and multi-object spectrograph at the Gran Telescopio Canarias. We have created MEGASTAR, an empirical library of stellar spectra obtained using MEGARA at high resolution R = 20 000 (FWHM), available in two wavelength ranges: one centered in Hα, from 6420 to 6790 Å and the other centered in the Ca ii triplet, from 8370 to 8885 Å (HR-R and HR-I VPH-grating configurations). In this work, we use MEGASTAR spectra, combination of these two short wavelength intervals, to estimate the stellar parameters namely effective temperature, surface gravity and metallicity (and their associated errors) for a sample of 351 MEGASTAR members with spectral types earlier than B2. We have applied a χ^(2) technique by comparing MEGASTAR data to theoretical stellar models. For those stars with stellar parameters derived in the literature, we have obtained a good agreement between those published parameters and ours. Besides the stellar parameters, we also provide several products like the rectified spectra, radial velocities and stellar indices for this sample of stars. In a near future, we will use MEGASTAR spectra and their derived stellar parameters to compute stellar population evolutionary synthesis models, which will contribute to a better interpretation of star clusters and galaxies spectra obtained with MEGARA.Depto. de Física de la Tierra y AstrofísicaFac. de Ciencias FísicasTRUEMinisterio de Ciencia e InnovaciónAgencia Estatal de InvestigaciónFRACTALNextGeneration EU/PRTR and MIU through a Margarita Salas grantEuropean Regional Development Funds (ERDF), through Programa Operativo Canarias FEDER 2014-2020INAOECIEMATpu

Manejo intervencionista de una insuficiencia mitral por pseudocleft en paciente pluripatológico

We report a case of heart failure with poor response to conventional medical treatment in a multi-pathological patient with severe mitral valve insufficiency secondary to pseudocleft in which an interventional approach was decided with a MitraClip implant. This clinical case describes the importance of a multidisciplinary approach in the treatment of heart failure patients by integrating multiples areas of cardiology such as clinical, advanced imaging and percutaneous interventions.Se presenta un caso de insuficiencia cardíaca refractaria a tratamiento médico en paciente pluripatológico con insuficiencia mitral grave por pseudocleft en el que se decide un manejo intervencionista con implante de MitraClip. Este caso destaca la importancia del manejo multidisciplinar de la insuficiencia cardíaca integrando distintas áreas de la cardiología como la clínica, la imagen avanzada y el intervencionismo percutáneo

MEGARA-GTC stellar spectral library: I

MEGARA (Multi Espectrografo en GTC de Alta Resolucion para Astronomia) is an optical (3650-9750 Å), fibre-fed, medium-high spectral resolution (R = 6000, 12 000 and 20 000) instrument for the Gran Telescopio CANARIAS (GTC) 10.4-m telescope, commissioned in the summer of 2017, and currently in operation. The scientific exploitation of MEGARA requires a stellar spectra library to interpret galaxy data and to estimate the contribution of the stellar populations. In this paper, we introduce the MEGARA-GTC spectral library, detailing the rationale behind the building of this catalogue. We present the spectra of 97 stars (21 individual stars and 56 members of the globular cluster M15, which are both subsamples taken during the commissioning runs, and 20 stars from our ongoing GTC Open-Time programme). The spectra have R = 20 000 in the HR-R and HR-I set-ups, centred at 6563 and 8633 Å, respectively. We describe the procedures to reduce and analyse the data. Then, we determine the best-fitting theoretical models to each spectrum through a χ^(2) minimization technique, to derive the stellar physical parameters, and we discuss the results. We have also measured some absorption lines and indices. Finally, we introduce our project to complete the library and the data base in order to make the spectra available to the community

The nature of the Cygnus extreme B supergiant 2MASS J20395358+4222505

2MASS J20395358+4222505 is an obscured early B supergiant near the massive OB star association Cygnus OB2. Despite its bright infrared magnitude (Ks = 5.82) it has remained largely ignored because of its dim optical magnitude (B = 16.63, V = 13.68). In a previous paper, we classified it as a highly reddened, potentially extremely luminous, early B-type supergiant. We obtained its spectrum in the U, B and R spectral bands during commissioning observations with the instrument MEGARA at the Gran Telescopio CANARIAS. It displays a particularly strong Hα emission for its spectral type, B1 Ia. The star seems to be in an intermediate phase between supergiant and hypergiant, a group that it will probably join in the near (astronomical) future. We observe a radial velocity difference between individual observations and determine the stellar parameters, obtaining Teff = 24 000 K and log gc = 2.88 ± 0.15. The rotational velocity found is large for a B supergiant, v sin i = 110 ± 25 kms−1⁠. The abundance pattern is consistent with solar, with a mild C underabundance (based on a single line). Assuming that J20395358+4222505 is at the distance of Cyg OB2, we derive the radius from infrared photometry, finding R = 41.2 ± 4.0 R⊙, log(L/L⊙) = 5.71 ± 0.04 and a spectroscopic mass of 46.5 ± 15.0 M⊙. The clumped mass-loss rate (clumping factor 10) is very high for the spectral type, M˙ = 2.4 × 10−6 M⊙ a−1. The high rotational velocity and mass-loss rate place the star at the hot side of the bi-stability jump. Together with the nearly solar CNO abundance pattern, they may also point to evolution in a binary system, J20395358+4222505 being the initial secondary.SS-D and AH acknowledge support from the Spanish Government Ministerio de Ciencia e Innovación through grants PGC-2018-091 3741-B-C22 and CEX2019-000920-S and from the Canarian Agency for Research, Innovation and Information Society (ACIISI), of the Canary Islands Government, and the European Regional Development Fund (ERDF), under grant with reference ProID2020010016. MG and FN acknowledge financial support through Spanish grant PID2019-105552RB-C41 (MINECO/MCIU/AEI/FEDER) and from the Spanish State Research Agency (AEI) through the Unidad de Excelencia ‘María de Maeztu’-Centro de Astrobiología (CSIC-INTA) project No. MDM-2017-0737. SRB acknowledges support by the Spanish Government under grants AYA2015-68012-C2-2-P and PGC2018-093741-B-C21/C22 (MICIU/AEI/FEDER, UE). SRA acknowledges funding support from the FONDECYT Iniciación project 11171025 and the FONDECYT Regular project 1201490. JIP acknowledges finantial support from projects Estallidos6 AYA2016-79724-C4 (Spanish Ministerio de Economia y Competitividad), Estallidos7 PID2019-107408GB-C44 (Spanish Ministerio de Ciencia e Innovacion), grant P18-FR-2664 (Junta de Andalucía), and grant SEV-2017-0709 ‘Centro de Excelencia Severo Ochoa Program’ (Spanish Science Ministry). AGP, SP, AG-M, JG and NC acknowledge support from the Spanish MCI through project RTI2018-096188-B-I00

Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course

BACKGROUND: It remains unclear whether disease course in multiple sclerosis (MS) is influenced by genetic polymorphisms. Here, we aimed to identify genetic variants associated with benign and aggressive disease courses in MS patients. METHODS: MS patients were classified into benign and aggressive phenotypes according to clinical criteria. We performed exome sequencing in a discovery cohort, which included 20 MS patients, 10 with benign and 10 with aggressive disease course, and genotyping in 2 independent validation cohorts. The first validation cohort encompassed 194 MS patients, 107 with benign and 87 with aggressive phenotypes. The second validation cohort comprised 257 patients, of whom 224 patients had benign phenotypes and 33 aggressive disease courses. Brain immunohistochemistries were performed using disease course associated genes antibodies. RESULTS: By means of single-nucleotide polymorphism (SNP) detection and comparison of allele frequencies between patients with benign and aggressive phenotypes, a total of 16 SNPs were selected for validation from the exome sequencing data in the discovery cohort. Meta-analysis of genotyping results in two validation cohorts revealed two polymorphisms, rs28469012 and rs10894768, significantly associated with disease course. SNP rs28469012 is located in CPXM2 (carboxypeptidase X, M14 family, member 2) and was associated with aggressive disease course (uncorrected p value < 0.05). SNP rs10894768, which is positioned in IGSF9B (immunoglobulin superfamily member 9B) was associated with benign phenotype (uncorrected p value < 0.05). In addition, a trend for association with benign phenotype was observed for a third SNP, rs10423927, in NLRP9 (NLR family pyrin domain containing 9). Brain immunohistochemistries in chronic active lesions from MS patients revealed expression of IGSF9B in astrocytes and macrophages/microglial cells, and expression of CPXM2 and NLRP9 restricted to brain macrophages/microglia. CONCLUSIONS: Genetic variants located in CPXM2, IGSF9B, and NLRP9 have the potential to modulate disease course in MS patients and may be used as disease activity biomarkers to identify patients with divergent disease courses. Altogether, the reported results from this study support the influence of genetic factors in MS disease course and may help to better understand the complex molecular mechanisms underlying disease pathogenesis

A new insight of AGC 198691 (Leoncino) galaxy with MEGARA at the GTC

We describe the observations of the low metallicity nearby galaxy AGC 198691 (Leoncino Dwarf) obtained with the Integral Field Unit of the instrument MEGARA at the Gran Telescopio Canarias. The observations cover the wavelength ranges 4304-5198 Aand 6098-7306 Awith a resolving power R approximate to 6000. We present 2D maps of the ionized gas, deriving the extension of the H II region and gas kinematics from the observed emission lines. We have not found any evidence of recent gas infall or loss of metals by means of outflows. This result is supported by the closed-box model predictions, consistent with the oxygen abundance found by other authors in this galaxy and points towards Leoncino being a genuine XMD galaxy. We present for the first time spatially resolved spectroscopy allowing the detailed study of a star-forming region. We use POPSTAR + CLOUDY models to simulate the emission-line spectrum. We find that the central emission-line spectrum can be explained by a single young ionizing cluster with an age of approximate to 3.5 +/- 0.5 Myr and a stellar mass of approximate to 2 x10(3) M-circle dot. However, the radial profiles of [O III].5007Aand the Balmer lines in emission demand photoionization by clusters of different ages between 3.5 and 6.5 Myr that might respond either to the evolution of a single cluster evolving along the cooling time of the nebula (approximate to 3 Myr at the metallicity of Leoncino, Z approximate to 0.0004) or to mass segregation of the cluster, being both scenarios consistent with the observed equivalent widths of the Balmer lines

Actualización e internacionalización del catálogo "OSCAR" de experiencias de Física General

En convocatorias anteriores de la convocatorias de Proyectos de Innovación Docente de l UCM, la última de ellas correspondiente a 2014, desarrollamos un Catálogo de experiencias de cátedra para la docencia de Física General, OSCAR. En esta edición los hemos ampliado con nuevas experiencias. Asimismo se ha desarrollado un programa de visitas de colegios a la Facultad de Ciencias Físicas de la UCM